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Cohesive-Adhesive Balance (CAB)
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The cohesive-adhesive balance (CAB™) approach of the AFM colloid probe technique is a novel development pioneered by Nanopharm Ltd, enabling direct quantification of the cohesive and adhesive nature - "the force balance" of an API within a formulation. Nanopharm Ltd has developed the CAB™ approach as a novel screening tool in determining the cohesive/adhesive force interactions between potential formulation components using milligrams or less of material. The CAB™ approach measures the forces of interaction between API particles, mounted as colloid AFM probes, and well-defined crystalline surfaces of the API and carrier substrates. A CAB™ plot generated from the interaction of a number of probes allows a characteristic measurement of the cohesive nature of the API, in relation to its adhesive propensity with an excipient material to be quantified, as illustrated in the schematic representation. The development of the CAB™ approach has overcome a number of the limitations associated with conventional AFM colloid probe methodologies, including issues regarding instrumental validation and the need to determine the true area of contact of the interacting surfaces. Case studies describing the use of CAB™ approach in charactering the force balance of binary formulations are available via the following link. Back to Technology ›› |
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